Syllabus(Structural and Functional Biosciences for Animals)

Doctoral Program

No. Title Instructor Credit Semester Notes
Special Method and Practice in Advanced Veterinary Science All faculty members 1 Oct-Mar Compulsory
Special Seminar: Structural and Functional Biosceneces for Animals A All faculty members 2 Apr-Sep Compulsory
Special Seminar: Structural and Functional Biosceneces for Animals B All faculty members 2 Oct-Mar Compulsory
Special Seminar: Structural and Functional Biosceneces for Animals C All faculty members 2 Apr-Sep Compulsory
Special Study: Structural and Functional Biosceneces for Animals A All faculty members 2 Apr-Sep Compulsory
Special Study: Structural and Functional Biosceneces for Animals B All faculty members 2 Oct-Mar Compulsory
Special Study: Structural and Functional Biosceneces for Animals C All faculty members 2 Apr-Sep Compulsory
Special Study: Structural and Functional Biosceneces for Animals D All faculty members 2 Oct-Mar Compulsory
Special Study: Structural and Functional Biosceneces for Animals E All faculty members 2 Apr-Sep Compulsory
Special Study: Structural and Functional Biosceneces for Animals F All faculty members 2 Oct-Mar Compulsory
Special Study: Structural and Functional Biosceneces for Animals G All faculty members 2 Apr-Sep Compulsory
Special Study: Structural and Functional Biosceneces for Animals H All faculty members 2 Oct-Mar Compulsory
Special Lecture: Integrated Structural Biosciences A Kazushige OGAWA, Takayuki NAKAJIMA 1 Apr-Sep
Special Lecture: Integrated Structural Biosciences B Jyoji YAMATE, Mitsuru KUWAMURA,Takeshi IZAWA 1 Oct-Mar
Special Lecture: Integrated Structural Biosciences C Toshiya OKADA 1 Oct-Mar
Special Lecture: Ingegrated Functional Biosciences A Yoichi NAKAMURA, Mitsuaki MORIYAMA,Katsura TAKANO 1 Apr-Sep
Special Lecture: Ingegrated Functional Biosciences B Tadayoshi TAKEUCHI, Yasutaka AZUMA, Hidemitsu NAKAJIMA 1 Apr-Sep
Special Lecture: Ingegrated Functional Biosciences C Masayuki KOMORI, Shigeo TAKENAKA 1 Oct-Mar
Special Practice for up-to-date Instrument Application All faculty members 1 Oct-Mar
Special Lecture for Animal Ethics Toshiya OKADA 1 Apr-Sep
Internship for Advanced Veterinary Sciences All faculty members 1 Year-round
Special Lecture: Structural and Functional Biosciences for Animals TBD 2 Apr-Sep intensive course
Special Lecture: Animal Biotechnology TBD 2 Apr-Sep intensive course

Notes

1. You must obtain at least a total of 31 credits, comprised of 24 credits for compulsory subjects, including ‘Research Integrity B’ of the Graduate School Common Courses, and 7 credits for elective subjects

2. Of the 7 credits for elective subjects, 4 credits may be from other fields in the Division of Veterinary Science.

3. Among the elective courses from other fields, ‘Technology-based-Entrepreneurship Course II’ (1 credit) from the Graduate School Common Courses may also be included.
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Doctoral Program

Title Special Methods and Practice in Advanced Veterinary Science
Instructors Faculty of the Department of Veterinary Environmental Sciences
Course Objectives The goal of this course is to obtain basic knowledge and technology for the latest investigative approaches in order to acquire the abilities for developing an advanced research originally, and for accomplishing research independently.
Description and program The research seminar, which is usually held in each laboratory, will be held by the department or division. Research development will be improved by question-and-answer sessions, and by discussion with the researchers in different laboratories.

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Title Special Seminar: Structural and Functional Biosciences for Animals A
Instructors Faculty of the Department of Structural and Functional Biosciences for Animals
Course Objectives The goal of this course is to acquire advanced expertise in veterinary science and related areas, especially in the Department of Structural and Functional Bioscience for Animals being composed of Veterinary Anatomy, Veterinary Pathology, Laboratory Animal Science, Applied Pharmacology, Integrative Physiology, and Cellular and Molecular Biology.
Description and program Advanced expertise in Structural and Functional Bioscience for Animals or related areas is acquired. Bibliographical survey of recent research trends through discussion with the academic supervisor will be summarized and a presentation made in order to develop problem analysis and proposal abilities for research in these areas.

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Title Special Seminar: Structural and Functional Biosciences for Animals B
Instructors Faculty of the Department of Structural and Functional Biosciences for Animals
Course Objectives The goal of this course is to acquire advanced expertise in veterinary science and the related area, especially in the Department Structural and Functional Bioscience for Animals being composed of Veterinary Anatomy, Veterinary Pathology, Laboratory Animal Science, Applied Pharmacology, Integrative Physiology, and Cellular and Molecular Biology.
Description and program Presentation of a research article review should be made at the assembly of the Division of Veterinary Science on a specific topic in Veterinary Sciences or Structural and Functional Biosciences for Animals. In the review presentation, extensive recent knowledge from many research articles should be summarized and organized with additional personal opinions. The abstract of the review presentation should be distributed in advance to all faculties and postgraduate students in the Division of Veterinary Science in order to facilitate better discussion. Participation in the discussion is mandatory.

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Title Special Seminar: Structural and Functional Biosciences for Animals C
Instructors Faculty of the Department of Structural and Functional Biosciences for Animals
Course Objectives The goal of this course is to acquire advanced expertise in veterinary science and the related area, especially in the Department of Animal Structure and Functions being composed of Veterinary Anatomy, Veterinary Pathology, Laboratory Animal Science, Applied Pharmacology, Integrative Physiology, and Cellular and Molecular Biology.
Description and program The ability to evaluate and analyze as a researcher and/or educator is cultivated by extensive reading of research articles relates to the doctoral thesis. In addition, information on research and careers after graduate school is acquired by understanding the latest research directions in biological areas through discussion with academic supervisors.

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Title Special Study: Structural and Functional Biosciences for Animals A
Instructors Faculty of the Department of Structural and Functional Biosciences for Animals
Course Objectives The goal of this course is to acquire specialized skills and problem-solving abilities necessary to plan, execute, evaluate, and summarize research in the Department of Animal Structure and Functions being composed of Veterinary Anatomy, Veterinary Pathology, Laboratory Animal Science, Applied Pharmacology, Integrative Physiology, and Cellular and Molecular Biology.
Description and program Under the supervision of academic supervisors in the major subject, understanding and analyzing information on recent research directions will develop the ability to focus on personal topics including original research proposals. Problem analysis and proposal abilities are developed.

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Title Special Study: Structural and Functional Biosciences for Animals B
Instructors Faculty of the Department of Structural and Functional Biosciences for Animals
Course Objectives The goal of this course is to acquire specialized skills and problem-solving abilities necessary to plan, execute, evaluate, and summarize the research in the Department of Animal Structure and Functions being composed of Veterinary Anatomy, Veterinary Pathology, Laboratory Animal Science, Applied Pharmacology, Integrative Physiology, and Cellular and Molecular Biology.
Description and program To carry out experiments on research subjects under discussion with academic supervisors. Analysis of the results and trouble-shooting will develop conflict-resolution skills, that are necessary to independently plan and execute future research.

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Title Special Study: Structural and Functional Biosciences for Animals C
Instructors Faculty of the Department of Structural and Functional Biosciences for Animals
Course Objectives The goal of this course is to acquire specialized skills and problem-solving abilities necessary to plan, execute, evaluate, and summarize the research in the Department of Animal Structure and Functions being composed of Veterinary Anatomy, Veterinary Pathology, Laboratory Animal Science, Applied Pharmacology, Integrative Physiology, and Cellular and Molecular Biology.
Description and program Research plans will be improved through discussion with the members of the faculty other than the supervisor. New ideas for research methods, systematic recognition, assessment capability, and communications skills will be acquired.

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Title Special Study: Structural and Functional Biosciences for Animals D
Instructors Faculty of the Department of Structural and Functional Biosciences for Animals
Course Objectives The goal of this course is to acquire specialized skills and problem-solving abilities necessary to plan, execute, evaluate, and summarize research in the Department of Animal Structure and Functions being composed of Veterinary Anatomy, Veterinary Pathology, Laboratory Animal Science, Applied Pharmacology, Integrative Physiology, and Cellular and Molecular Biology.
Description and program A series of independent experiments and survey results are logically combined, discussed with the academic supervisor of the graduate school, presented at a research report association and related relevant societies, and the findings and problems with the study results are discussed. Logical thinking, presentation skills, and proceedings management ability are acquired.

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Title Special Study: Structural and Functional Biosciences for Animals E
Instructors Faculty of the Department of Structural and Functional Biosciences for Animals
Course Objectives The goal of this course is to acquire specialized skills and problem-solving abilities necessary to plan, execute, evaluate, and summarize research in the department of Animal Structure and Functions being composed of Veterinary Anatomy, Veterinary Pathology, Laboratory Animal Science, Applied Pharmacology, Integrative Physiology, and Cellular and Molecular Biology.
Description and program Specialized skills and problem-solving ability necessary to summarize the research and investigation are acquired for a research topic with advice from the academic supervisor of the graduate school. Independent research and investigation, reexamination of the problem, and the achievement level are confirmed, and future development is discussed with the graduate school academic supervisor.

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Title Special Study: Structural and Functional Biosciences for Animals F
Instructors Faculty of the Department of Structural and Functional Biosciences for Animals
Course Objectives The goal of this course is to acquire specialized skills and problem-solving abilities necessary to plan, execute, evaluate, and summarize research in the department of Animal Structure and Functions being composed of Veterinary Anatomy, Veterinary Pathology, Laboratory Animal Science, Applied Pharmacology, Integrative Physiology, and Cellular and Molecular Biology.
Description and program Midterm presentation: progress report on the recent research direction of the degree thesis and a series of the study results should be made to discuss with the faculty and students in the division. The abstract of the presentation should be distributed in advance to all faculty and postgraduate students in the Division of Veterinary Science in order to facilitate better discussion. Participation in the discussion is mandatory.

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Title Special Study: Structural and Functional Biosciences for Animals G
Instructors Faculty of the Department of Structural and Functional Biosciences for Animals
Course Objectives The goal of this course is to acquire specialized skills and problem-solving abilities necessary to plan, execute, evaluate, and summarize research in the department of Animal Structure and Functions being composed of Veterinary Anatomy, Veterinary Pathology, Laboratory Animal Science, Applied Pharmacology, Integrative Physiology, and Cellular and Molecular Biology.
Description and program Consideration of the research topic based on the obtained study results by investigating related literature, aiming at the content and submission to a scientific journal with review by the referees. The ability to publish research is acquired by writing a manuscript according to the contribution regulations and the comments by the referees is developed.

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Title Special Study: Structural and Functional Biosciences for Animals H
Instructors Faculty of the Department of Structural and Functional Biosciences for Animals
Course Objectives The goal of this course is to acquire specialized skills and problem-solving abilities necessary to plan, execute, evaluate, and summarize research in the department of Animal Structure and Functions being composed of Veterinary Anatomy, Veterinary Pathology, Laboratory Animal Science, Applied Pharmacology, Integrative Physiology, and Cellular and Molecular Biology.
Description and program Research topics in the major subject are discussed with the academic supervisor of the graduate school, and the series of experimentations and investigation is combined with reference to the latest information in a field of research to bring the doctoral thesis to completion.

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Title Special Lecture: Integrated Structural Biosciences A
Instructors Kazushige OGAWA, Takayuki NAKAJIMA (Veterinary Anatomy)
Course Objectives In multicellular organisms, intercellular signaling is indispensable for the maintenance of life. Full understanding of the signaling mechanism leads to a clear understanding of cell organization (tissue formation) and the maintenance of tissues and organs because the signaling controls regeneration, degeneration, proliferation, cell death and so on. This lecture aims at providing further information about molecules related to cell differentiation, proliferation and cell death as well as to cell adhesion, which are closely linked to and controlled by intercellular signaling. This lecture also introduces practical methods to investigate expressions and functions of molecules related to the intercellular signaling in vitro and in vivo.
Description and program In this lecture we introduce and discuss research methods necessary to investigate the mechanisms of
(1) the organization and maintenance of tissues and
(2) the regulation of cell death in degeneration processes. Moreover, we discuss new findings obtained by these methods with reference to up-to-date journal articles. This lecture deals with the following topics:
1-2: Practical methods related to cell and molecular biology.
3-4: Intercellular signaling involved in cell movement and adhesion, especially on the receptor tyrosine kinase Eph and its ligand ephrin.
5-6: Practical methods related to immunohistochemistry and biochemical techniques.
7-8: Change in cytoskeletal proteins and their related proteins during neuronal degeneration in brain.

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Title Special Lecture: Integrated Structural Biosciences B
Instructors Jyoji YAMATE, Mitsuru KUWAMURA, Takeshi IZAWA (Veterinary Pathology)
Course Objectives This lecture aims to provide students with understanding of the basic principles of pathological lesions seen in spontaneous and experimental diseases. The context of animal diseases and lesions includes neoplastic, drug-induced, genetic and infectious conditions at molecular, cellular, organ and whole body levels. Latest information obtained by morphological, biochemical, and molecular biological experiments will also be addressed. Moreover, related articles published in international journals will be read carefully to understand the mechanisms beyond the disruption of homeostasis under pathological conditions and ingenious phenomena of the animal body. In addition, the usefulness of animal models for various diseases will be explained to recognize beneficial applications in biomedical research.
Description and program The following items on the latest findings obtained by the morphological (microscopy, immunohistochemistry, and electron microscopy etc), biochemical and molecular biological techniques will be addressed, with reading and intensive discussions.
Tumors in animals ( 2 )
Drug-induced diseases ( 2 )
Genetic diseases ( 2 )
Infectious diseases ( 2 )

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Title Special Lecture: Integrated Structural Biosciences C
Instructors Toshiya OKADA (Laboratory Animal Science)
Course Objectives Laboratory animal science is the integrative study of laboratory animals aimed at gaining biological knowledge necessary for understanding diverse biological phenomena in the biomedical sciences.
This field of science involves a comparative biological approach of different animals and humans. It also involves implementing various methodologies derived from recent developments in molecular and cell biology.
This course emphasizes logical integration of the latest knowledge while dealing with the theories and techniques of developing and improving laboratory animals with specific phenotypes, including those pertaining to diseases. We will also cover the methodology for understanding the causes of these phenotypes.
By taking this course, students will better understand the importance of laboratory animals. In addition to animal welfare and alternative approaches, they will be taught proper experimental procedures that generate accurate results while simultaneously relieving the animal of pain.
Description and program In this course, we will explore the latest findings in relevant fields and discuss possible future directions for improving current research methods. Our goals are to develop accurate and sophisticated expertise in each topic and enhance our knowledge and skills necessary for reading and writing scientific papers.
1. Proper Animal Testing and Animal Welfare (2 classes)
2. Analysis of Congenital Cataracts (2 classes)
3. Behavioral Analysis of the Mongolian Gerbil (2 classes)
4. Factors Affecting Kidney Development (2 classes)

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Title Special Lecture: Integrated Functional Biosciences A
Instructors Yoichi NAKAMURA, Mitsuaki MORIYAMA, Katsura TAKANO (Integrative Physiology)
Course Objectives The integration of biological regulations involves interactions among the endocrine, nervous and immune systems. The function of the central neurons is controlled by surrounding neuroglia and the neurons regulate the function of immunocytes. In addition, the peripheral metabolism is controlled by integration of the three systems described above. Some central diseases are caused by hyper-activation of brain macrophages (microglia), neuronal abnormality can cause dysfunction of the immune system, and hepatic metabolic dysfunction also causes central diseases. The integrative regulation of the three systems is the most important point of view in animal physiology.
Description and program This year, the central nervous system is the main subject centering on the cellular physiological chemistry of the neurons and neuroglia, including abnormal modulation of their functions. The following topics are scheduled.
Lecture 1: Discourse on methods in neuroscience
Lecture 2: Structure and function of the brain
Lecture 3: Neural network of the senses
Lecture 4: Regulation of cellular functions in glia and neurodegenerative diseases
Lecture 5: Physiology in Obesity

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Title Special Lecture: Integrated Functional Biosciences B
Instructors Tadayoshi TAKEUCHI, Yasutaka AZUMA, Hidemitsu NAKAJIMA (Veterinary Pharmacology)
Course Objectives Basic knowledge related to new drug development can generally be divided into steps. The first studies focus on the action mechanisms of chemicals at the molecular and cellular levels. Next step is to understand the structure-activity relationships of the drugs. In addition, the latest findings of neurotransmitters, hormones and physiological active substances affecting intercellular signaling are explained in detail, and their information at the protein, membrane and cellular levels regarding intracellular signaling are lectured by a pharmacological point of view. The adjustment and integrated functions in the biosignal transmission system are understood from these lectures. In addition, the relationship between these functional changes and disease, and the action of drugs on diseases will be addressed to understand.
Description and program The action points and mechanisms of drugs based on the latest research in the gut, brain and immune system will be addressed. Accurate and advanced expertise are achieved for each item, drug mechanisms are reforced and basic knowledge on new drugs development is supported.
1. Action mechanism and structure-activity relationships of drugs (2 lectures)
The action mechanism of drugs is understood at the molecular, cellular and whole-body levels, and the relationship between the action of drugs and their structure are understood.
2. Physiological function and pharmacology in of the gut (3 lectures)
We let you learn basic knowledge necessary to understand the function and structure of intestinal tracts that change in the disease and actions of drugs.
3. Pharmacology in the central nervous system (1 lecture)
The action mechanisms of drugs that act on higher-order functions of the brain and the viewpoint of new drug development are explained.
4. Pharmacology in the immune system (2 lectures)
Biologically active substances in the immunological system and their intracellular mechanism, drugs that act on immunity, and new drug development from the viewpoint of the immunological system are explained.
5. Preliminary day (1 lecture)

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Title Special Lecture: Integrated Functional Biosciences C
Instructors Masayuki KOMORI, Shigeo TAKENAKA (Cellular and Molecular Biology)
Course Objectives Theory and knowledge of biochemistry, molecular biology, and cell biology are very important for understanding various life phenomena at the molecule or cell level, and importance has increased more and more in the field of animal biotechnology including basic veterinary science. Thus, in this lecture we discuss the latest topics about the intracellular protein sorting, the function of subcellular organelle, the mechanisms of organelle homeostasis, and the application of systems biology to the pathobiological analysis (e.g. genomics), in order to understand the theory and the applied technology of above study areas.
Description and program We lecture on the following item with explanation of the latest findings of the related area. Moreover, specialized and advanced knowledge concerning each item is obtained by doing the presentation and the question and answer about the recent journal articles as well as it supports to get the ability to understand and prepare the research paper.
1. Structure and function of subcellular organelle
2-3. Mechanism of protein sorting
4. Mechanism of organelle homeostasis
5-6. Systems biology
7-8. Application to pathobiological analysis

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Title Special Practice for up-to-date Instrument Application
Instructors Faculty in the Division of Veterinary Science
Course Objectives The goal of this course is to obtain the principles and limitations of the latest technologies in bioscience in order to carry out independent quality research.
Description and program Learning the principles and limitations of the latest technologies in bioscience is indispensable for the development of independent research. It should be recognized what is possible using novel scientific equipment. Concrete experience of the apparatus may enable its application in independent research.

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Title Special Lecture on Animal Ethics
Instructors Toshiya OKADA (Laboratory Animal Science)
Course Objectives In this lecture, we will investigate the laws and regulations concerning animal welfare and the ethical discipline necessary for scientists using live animals.
Description and program The laws and regulations discussed in this lecture include the following: Law for the Humane Treatment and Management of Animals and its related legal information (Standards Relating to the Care and Management of Laboratory Animals and Relief of Pain; Guidelines on Methods of Sacrificing Laboratory Animals; Standards Relating to the Care and Management of Pets, Standards Relating to the Care and Management of Domestic Animals; Standards Relating to the Care and Management of Animals for Exhibition; and Invasive Alien Species Law), Law Concerning the Conservation and Sustainable Use of Biological Diversity through Regulations on the Use of Living Modified Organisms and Law concerning Prevention of Infectious Diseases and Medical Care for Patients with Infectious Diseases.
We will also examine the welfare of various animals, including domestic animals, companion animals, animals for exhibition and laboratory animals, and discuss ethical issues surrounding the relationship between humans and animals.

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Title Internship for Advanced Veterinary Science
Instructors Faculty of the Division of Veterinary Science
Course Objectives The goal of this course is to experience occupational positions in order to increase the possibility of obtaining a position as a researcher or professional scientific investigator.
Description and program